According to Billboard, the 30-year-old entertainer is filling in for Bey, who had to drop out of the festival due to her pregnancy.
This is certainly a huge year for Gaga, who already headlined the Super Bowl Halftime Show and gave an amazing performance at the Grammys alongside Metallica.
It was important to Coachella organizers that a female performer replaces Beyoncé, insiders tell Billboard, making Gaga the first woman to headline Coachella since Björk in 2007.
Lady Gaga will be joined at Coachella by fellow headliners Radiohead and Kendrick Lamar, as well as the XX, Bon Iver, Future, Lorde, and Justice. The festival runs April 14-16 and April 21-23.